Patrick E Duffy Selected Research

Chondroitin Sulfates (Chondroitin Sulfate)

1/2022	An Invariant Protein That Colocalizes With VAR2CSA on Plasmodium falciparum-Infected Red Cells Binds to Chondroitin Sulfate A.
11/2021	Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity.
1/2021	Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.
1/2016	VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to Plasmodium falciparum Placental Malaria.
2/2013	Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria.
4/2008	VAR2CSA domains expressed in Escherichia coli induce cross-reactive antibodies to native protein.
4/2008	Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA.
7/2007	Effects of sex, parity, and sequence variation on seroreactivity to candidate pregnancy malaria vaccine antigens.
4/2004	Mass spectrometric analysis of Plasmodium falciparum erythrocyte membrane protein-1 variants expressed by placental malaria parasites.
11/2003	Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns.

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Patrick E Duffy Research Topics

Disease

149	Malaria 10/2022 - 07/2002
47	Infections 01/2022 - 07/2003
19	Parasitemia 01/2021 - 08/2003
11	Anemia 01/2021 - 10/2002
9	Falciparum Malaria (Plasmodium falciparum Malaria) 09/2020 - 08/2005
7	Birth Weight (Birth Weights) 09/2012 - 11/2003
5	Iron Deficiencies 01/2021 - 07/2008
4	Reinfection 06/2021 - 09/2005
4	Bites and Stings (Sting) 01/2021 - 06/2014
4	Inflammation (Inflammations) 12/2017 - 01/2008
3	Hemolysis 01/2022 - 01/2014
2	Cerebral Malaria 01/2020 - 10/2002
2	Communicable Diseases (Infectious Diseases) 01/2019 - 02/2010
2	Fever (Fevers) 01/2017 - 04/2015
2	HIV Infections (HIV Infection) 01/2017 - 01/2014
2	Opportunistic Infections (Opportunistic Infection) 01/2017 - 12/2012
2	Parasitic Diseases (Parasitic Disease) 12/2015 - 11/2015
2	Pre-Eclampsia (Preeclampsia) 09/2008 - 11/2006
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2021
1	Thalassemia 01/2021
1	Persistent Infection 01/2019
1	Typhoid Fever (Typhoid) 01/2018
1	Hepatitis C 01/2018
1	Hepatitis B 01/2018

Drug/Important Bio-Agent (IBA)

66	VaccinesIBA 10/2022 - 07/2003
33	AntibodiesIBA 10/2022 - 07/2003
29	AntigensIBA 01/2022 - 04/2004
22	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2005
12	CytokinesIBA 01/2021 - 10/2002
11	Chondroitin Sulfates (Chondroitin Sulfate)IBA 01/2022 - 07/2002
11	Malaria VaccinesIBA 01/2022 - 03/2005
10	Pharmaceutical PreparationsIBA 12/2020 - 08/2005
9	Immunoglobulin G (IgG)IBA 01/2022 - 08/2005
9	IronIBA 01/2021 - 07/2007
8	pyrimethamine drug combination fanasil (Fansidar)FDA Link 02/2022 - 08/2011
8	Membrane Proteins (Integral Membrane Proteins)IBA 11/2021 - 08/2003
7	Antimalarials (Antimalarial Agents)IBA 12/2020 - 12/2005
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2017 - 10/2002
6	1- acetyl- 1,2,3,3a,8,8a- hexahydro- 8a- hydroxy- 5- methoxypyrrolo(2,3- b)indole (CHMI)IBA 01/2022 - 01/2014
6	Biomarkers (Surrogate Marker)IBA 01/2020 - 11/2006
5	Hemoglobins (Hemoglobin)IBA 01/2022 - 08/2011
5	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 12/2020 - 12/2012
5	ProteomeIBA 01/2020 - 09/2007
5	HepcidinsIBA 12/2017 - 07/2007
4	Plasmodium falciparum erythrocyte membrane protein 1IBA 06/2021 - 04/2004
4	Carrier Proteins (Binding Protein)IBA 01/2020 - 01/2010
4	Interleukin-10 (Interleukin 10)IBA 01/2019 - 01/2008
3	Amodiaquine (Camoquin)FDA Link 02/2022 - 01/2017
3	Peptides (Polypeptides)IBA 01/2022 - 07/2007
3	Conjugate VaccinesIBA 12/2021 - 01/2016
3	Complement System Proteins (Complement)IBA 10/2021 - 12/2011
3	EpitopesIBA 01/2021 - 12/2010
3	Interleukin-6 (Interleukin 6)IBA 01/2021 - 10/2002
3	InsecticidesIBA 03/2020 - 02/2016
3	Ritonavir (Norvir)FDA Link 01/2018 - 01/2014
3	Lopinavir FDA Link 01/2018 - 01/2014
3	HIV Protease InhibitorsIBA 01/2018 - 01/2014
3	Hormones (Hormone)IBA 12/2017 - 07/2012
3	ChemokinesIBA 10/2017 - 11/2010
3	LigandsIBA 01/2013 - 11/2010
3	Interferon-gamma (Interferon, gamma)IBA 09/2012 - 10/2002
2	Freund's AdjuvantIBA 01/2022 - 01/2017
2	Chloroquine (Aralen)FDA LinkGeneric 01/2021 - 12/2020
2	18S Ribosomal RNAIBA 01/2019 - 03/2012
2	Surface Antigens (Surface Antigen)IBA 03/2018 - 07/2002
2	NucleosidesIBA 01/2018 - 01/2016
2	Combined VaccinesIBA 01/2018 - 01/2016
2	Reverse Transcriptase InhibitorsIBA 01/2018 - 01/2016
2	Nevirapine (Viramune)FDA Link 01/2018 - 01/2016
2	Folic Acid AntagonistsIBA 01/2018 - 01/2014
2	InterferonsIBA 10/2017 - 10/2002
2	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 04/2015
2	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 09/2008 - 11/2006
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2022
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2022
1	Broadly Neutralizing AntibodiesIBA 01/2022
1	Viral ProteinsIBA 01/2021
1	Erythropoietin FDA Link 01/2021
1	Monoclonal AntibodiesIBA 01/2021
1	Pyrimethamine (Daraprim)FDA Link 01/2021
1	Primaquine FDA Link 12/2020
1	Aluminum Hydroxide (Algeldrate)FDA Link 11/2020
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 09/2020
1	Histidine (L-Histidine)FDA Link 09/2020
1	Glutamic Acid (Glutamate)FDA Link 01/2020
1	Cell-Free Nucleic AcidsIBA 01/2020
1	Deoxyribonucleases (DNase)FDA Link 01/2020
1	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2020
1	HaptoglobinsIBA 12/2019
1	N-acetyltalosaminuronic acid (NAT)IBA 01/2019
1	Immunoglobulin A (IgA)IBA 01/2019
1	Interleukin-5 (Interleukin 5)IBA 01/2019
1	Immunoglobulin E (IgE)IBA 01/2019
1	Typhoid-Paratyphoid Vaccines (Typhoid Vaccines)FDA Link 01/2018
1	Sulfamethoxazole FDA LinkGeneric 01/2018
1	NanovaccinesIBA 01/2018

Therapy/Procedure

8	Chemoprevention 02/2022 - 01/2017
5	Therapeutics 11/2020 - 04/2015
2	Ambulatory Care (Outpatient Care) 01/2021 - 11/2010
2	Aftercare (After-Treatment) 09/2005 - 08/2005